MethylPro L-Methylfolate 10mg 30ct delivers pharmaceutical-grade L-5-Methyltetrahydrofolate (L-5-MTHF) — the active, immediately bioavailable form of folate that bypasses the MTHFR enzymatic conversion step that affects approximately 40% of the population. At 10mg, this is a high-dose clinical formula for MTHFR homozygous presentations, high-demand methylation support, and as an adjunct in treatment-resistant depression protocols (the dose range studied alongside antidepressants).

L-5-MTHF is the only form of folate that directly participates in the methylation cycle — donating its methyl group to convert homocysteine to methionine (via methionine synthase), supporting SAMe synthesis for neurotransmitter production, and enabling DNA synthesis and repair. Unlike folic acid, which requires the MTHFR enzyme to convert to L-5-MTHF, supplemental L-5-MTHF works regardless of MTHFR genotype. MethylPro uses Quatrefolic® [(6S)-5-Methyltetrahydrofolic acid glucosamine salt] — the most stable and soluble form of L-methylfolate available. Excipient-free. MethylPro is a physician-grade supplement brand from Metabolic Maintenance's L-methylfolate line, providing pharmaceutical-grade L-5-MTHF (as Quatrefolic® or equivalent) — the active, bioavailable form of folate that bypasses the MTHFR conversion step affecting ~40% of the population. Available at Beauty Riche with same-day shipping.

MethylPro L-Methylfolate 10mg 30 Capsules – High-Dose Active Folate