SkinMedica Retinol Complex 0.5 is the intermediate step in SkinMedica's physician-formulated retinol regimen — delivering 0.5% encapsulated retinol for visible anti-aging results in patients who have pre-conditioned their skin with Retinol Complex 0.25 or another retinoid product. Encapsulation technology allows retinol to be released gradually into the skin, maximizing efficacy while significantly reducing the redness, peeling, and irritation associated with standard retinol formulas.

Retinol (0.5%) is encapsulated in PhytoShield™ Complex — SkinMedica's proprietary antioxidant complex that both protects the retinol molecule from oxidative degradation (increasing stability and shelf life) and buffers the skin against retinol-induced irritation during the adaptation period. This dual-function encapsulation is the key technical advantage of SkinMedica's retinol line over standard retinol creams that deliver retinol directly. Niacinamide supports the skin barrier during retinol use, reducing sensitivity and improving overall skin tone. Peptides provide complementary anti-aging support by stimulating collagen production through a separate, non-retinol pathway. Ceramides restore and maintain the lipid barrier that retinol use can temporarily compromise, reducing dryness and improving tolerance.

For use in the evening only. Not for use during pregnancy, lactation, or if planning to become pregnant. If new to retinol, begin twice weekly, increasing gradually to nightly as tolerated. Mild redness and peeling are expected during adaptation. Use SPF 30+ daily. Available at Beauty Riche — authorized SkinMedica retailer with same-day shipping.

SkinMedica Retinol Complex 0.5 1oz – Intermediate-Strength Anti-Aging Retinol