Microbiome Labs HU58 delivers a concentrated, high-potency dose of Bacillus subtilis HU58 — the single most clinically researched Bacillus strain and the one with the broadest and most impactful evidence base of the five strains in MegaSporeBiotic. For practitioners who want to focus specifically on the therapeutic properties of B. subtilis HU58 in higher concentration.

Bacillus subtilis HU58 produces more than 12 antibiotics — including Iturin, Bacillomycin, and Zwittermicin — that demonstrate activity against a wide range of pathogenic bacteria including H. pylori, Clostridium difficile, Campylobacter, E. coli, and Salmonella. It stimulates the production of short-chain fatty acids (particularly butyrate) that fuel colonocytes and maintain intestinal barrier integrity. It promotes the production of GABA — the primary inhibitory neurotransmitter regulating gut-brain signaling and intestinal motility — providing a potential mechanism for anxiolytic activity via the gut-brain axis. HU58 also specifically up-regulates immune tolerance through regulatory T-cell induction. At the higher concentration in HU58 standalone, these therapeutic benefits are amplified for clinical use. Microbiome Labs is a science-first probiotic and gut health supplement company founded by Dr. Kiran Krishnan, a research microbiologist, built around spore-based probiotic technology and clinical research on the human gut microbiome. Available at Beauty Riche with same-day shipping.

Microbiome Labs HU58 60 Capsules – High-Potency Bacillus subtilis HU58 Spore