Epicutis Hydrobiome Mist is a unique microbiome-balancing mist formulated to restore and maintain the skin microbiome ecosystem — the community of beneficial bacteria on the skin surface whose disruption underlies visible irritation, sensitivity, acne, and chronic barrier compromise. Powered by TCP, a patented TLR2 (Toll-Like Receptor 2) modulator developed by Signum Biosciences, with a postbiotic Lactobacillus and Maltodextrin prebiotic combination.

TCP (Disodium Tetramethylhexadecenylcysteine Formylprolinate) is a patented bioactive that modulates TLR2 — the pattern recognition receptor on keratinocytes and immune cells that responds to microbial signals. By modulating TLR2 signaling, TCP helps normalize the skin's inflammatory response to microbiome imbalance, supporting the growth of beneficial flora while calming irritation triggered by dysbiotic organisms (including C. acnes). This mechanism is fundamentally different from antibacterial approaches — it modulates the immune response to the microbiome rather than killing microorganisms. Sodium Tocopheryl Phosphate (water-soluble Vitamin E) provides antioxidant protection and strengthens the skin barrier. Lactobacillus postbiotic provides direct beneficial microbiome-supporting activity. Sodium Hyaluronate provides instant hydration with each spritz. Epicutis is a Princeton University-rooted clinical skincare brand founded by dermatologist Dr. Steven Rosen, M.D., built around patented lipid bioactive technology (TSC — Disodium Tetramethylhexadecenyl Succinoyl Cysteine) developed at Princeton University. Each formula is designed around a minimal, clean ingredient philosophy — only ingredients that serve a clear functional role. Available at Beauty Riche — authorized Epicutis retailer with same-day shipping.

Epicutis Hydrobiome Mist 1.7oz 50ml – Microbiome-Balancing Skin Mist